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 Symptoms of bone death in the jaw include:

• pain;
• swelling;
• infection of the gums;
• loosening of the teeth;
• poor healing of the gums;
• numbness or a feeling of heaviness in the jaw; and
• exposed bone.

Fosamax ® (generic name - Alendronate) is a type of drug known as bisphosphonates. Recently a link has been found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw (ONJ). This important discovery clearly shows that Fosamax ® side effects may include osteonecrosis of the jaw.

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 Zometa ® is a type of drug known as bisphosphonates. Recently a link has been found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw (ONJ). This important discovery clearly shows that Zometa ® side effects may include osteonecrosis of the jaw.

The discovery, published in the Journal of Oral and Maxillofacial Surgeons, prompted both the US, Food and Drug Administration (FDA) and Novartis, the manufacturer of bisphosphonates used in cancer chemotherapy, to issue a warning to health care professionals on September 24, 2004. The warning letter contained information about bisphosphonates and the risks of osteonecrosis in the jaw.

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Aredia ® is a type of drug known as bisphosphonates. Recently a link has been found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw (ONJ). This important discovery clearly shows that Aredia ® side effects may include osteonecrosis of the jaw.

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Actonel Jaw Osteonecrosis Lawsuit

Bisphosphonates are commonly used in tablet form such as Fosamax ® (Alendronate Sodium) and Actonel ® to prevent and treat osteoporosis in post-menopausal women. Stronger forms of bisphosphonates are commonly used in the management of advanced cancers that have metastasized to the bone, where the disease often causes bone pain and possibly even fractures. Several cancers can involve or metastasize to the bone, including lung cancer, breast cancer, prostate cancer, multiple myeloma, and others. When bisphosphonates are given in cancer chemotherapy, the drugs are given intravenously, and usually for longer periods of time.

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Bisphosphonate News

Drug linked to death of jawbone, USA TODAY
Salvatore Ruggiero was puzzled.Over a three-year period, the jaws
of dozens of patients who had undergone oral surgery
at his hospital had failed to heal properly.

Jaw Ailment Shows Industry Moves Slowly on Drug Warnings
THE WALL STREET JOURNAL, December 8, 2004; Page B1
After eight operations on patients whose jawbones turned out to be dead, oral surgeon Salvatore Ruggiero began doing some research....

Bisphosphonates Can Cause Problems in Jaw,
cancerpage.com (March 15, 2005) - Cancer patients given drugs called bisphosphonates to control
hypercalcemia – too much calcium in the blood – or the growth of bone metastases can develop bone death in the jaw the FDA warns.

The American Association of Oral and Maxillofacial Surgeons Bisphosphonates Can Wreak Havoc in the Mouth and Jaws, Oral and Maxillofacial Surgeon Warns ... onset of osteochemonecrosis,
or "bis-phossy jaw," a painful, potentially disfiguring jaw condition,
according ... increase the risk of bis-phossy jaw, it is the injectable medications

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The most common signs and symptoms of ONJ include pain, soft-tissue and jaw swelling, loosening of teeth, drainage, exposed bone, and infection.
Numbness, heaviness and other
sensations in the jaw may also occur in some individuals.
In order to diagnose ONJ, doctors may perform panoramic and tomographic imaging. They may also take microbial cultures and tissue biopsies in order to rule out other kinds of infections. Early detection of ONJ is imperative to preserving the jawbone.